The stability of the spirit as described in Donguibogam (Principles and Practice of Eastern Medicine) can be meaningfully understood through modern science as the harmony of brain function and autonomic nervous system balance. Experiencing anxiety every night and being unable to sleep can be seen as the result of disrupted complex neurological and endocrinological interactions in our brain.
Specifically, the emotion of anxiety is closely related to the overactivation of the amygdala located deep within the brain. The amygdala acts as the 'alarm center' of our emotions, detecting threats and triggering fear or anxiety reactions. When continuously exposed to stress factors during the day, this amygdala becomes overactive, exciting the sympathetic nervous system and preparing our body for a state of fight-or-flight. The heart beats faster, muscles tense, and the mind remains in a state of arousal.
If this state continues into the night, our body loses the hormone and neurotransmitter balance necessary to induce sleep. The secretion of melatonin, which signals the start of sleep, is suppressed, and the stress hormone cortisol remains high even at night. While cortisol normally helps us wake up in the morning, high levels at night interfere with deep sleep and reduce sleep quality. It's as if the brain is still busy at night as it is during the day.
Furthermore, the brain's Hypothalamic-Pituitary-Adrenal (HPA) axis is a core system that accommodates the stress response. Chronic anxiety and stress continuously stimulate this HPA axis, leading to increased nocturnal cortisol secretion and the induction of night sweats. This increases nocturnal arousal frequency and disrupts REM and NREM sleep patterns, thereby causing sleep fragmentation. Ultimately, this results in the feeling of 'sleeping but not feeling refreshed'.
Imbalance of neurotransmitters is also a significant cause. The function of inhibitory neurotransmitters like GABA, which plays an important role in anxiety alleviation and sleep induction, can decline. Or, an imbalance in serotonin, which accommodates mood and feelings of happiness, can fuel anxiety and depressive moods. These imbalances lead to changes in electroencephalogram (EEG), causing beta waves (a state of arousal) to dominate instead of alpha waves (a relaxation state) before sleep, thereby inducing insomnia.
In conclusion, what Donguibogam (Principles and Practice of Eastern Medicine) referred to as 'instability of the spirit' can be understood in modern medicine as occurring due to complex factors such as specific brain region overactivation, neurotransmitter imbalance, autonomic nervous system disturbance, and dysfunction of the hormone regulatory system. Modern science agrees that rather than simply taking hypnotic drugs to force sleep, truly achieving sweet sleep involves resolving the fundamental imbalance of the biological system that causes anxiety and finding the 'calmness of mind'.